Research

The Privileges of Exploration

Viridis Biopharma is recognized by the Government of India as a research organization. We have conducted numerous studies on efficacy, safety, and new indications for several of our associates to enhance product science. Research gives us a scientific basis to extend the areas of application for the products we deal with.

Apart from extensive safety and toxicity studies, Viridis has conducted several studies like the following:

Bactericidal activity of combination of Silver Water dispersion with 19 antibiotics against seven microbial strains

An in vitro study showed inhibition of MRSA by a combination of Silver water dispersion and penicillin-G suggesting more complete clearing of MRSA by of Silver water dispersion and penicillin G combination.

de Souza A, Mehta D, Leavitt RW. Bactericidal activity of combinations of silver-water dispersion with 19 antibiotics against seven microbial strains. Current Sciences. 2006;91 (7):926-29.

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Evaluation of safety and efficacy of barrier foam dressing in patients with exuding wound

Barrier Foam dressing combined with poly diallyl-dimethylammonium chloride – poly (DADMAC) has demonstrated good ability to absorb wound exudate, helps separation of necrotic tissue making debridement easier with no side effects or local reactions observed. This suggested that barrier foam dressing has favourable influence on wound healing process with good tolerance.

Gore M. Evaluation of safety and efficacy of barrier foam dressing in patients with exuding wound. (Data on file)

The ability of quaternary ammonium groups attached to a urethane bandage to inhibit bacterial attachment and biofilm formation in a mouse wound model.

Polyurethane foam coated with poly diallyl-dimethylammonium chloride Poly (DADMAC) used on the open wound of a mouse showed inhibition of both Gram-negative and Gram-positive bacteria under a dressing with total inhibition of biofilm formation. Poly DADMAC foam blocks the bacterial reservoir effect, commonly observed in dressings without poly DADMAC.

Tran PL, Huynh E, Hamood AN, et al. The ability of quaternary ammonium groups attached to a urethane bandage to inhibit bacterial attachment and biofilm formation in a mouse wound model. Int Wound J. 2015 ;14(1):79-84.

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A study on the ability of quaternary ammonium groups attached to a polyurethane foam wound dressing to inhibit bacterial attachment and biofilm formation

Polyurethane foam wound dressings coated with poly (DADMAC) show effective inhibition of growth of three main wound pathogens, S. aureus, P.aeruginosa and Acinetobacter baumannii, and their biofilm development within the wound and in the wound dressing.

Tran PL, Hamood AN, de Souza A, et al. A study on the ability of quaternary ammonium groups attached to a polyurethane foam wound dressing to inhibit bacterial attachment and biofilm formation. Wound Repair Regen. 2015;23(1):74-81.

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Antimicrobial Sensitivity Test and Kill Time Study of Amorphous Hydrogel with colloidal Silver, SilverSol® Vagigel on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Methicillin-resistant Staphylococcus aureus and Candida albicans in presence of simulant

SilverSol® Vagigel inhibits growth and multiplication of range of bacterial species including E. coli, S. aureus, P. aeruginosa, MRSA, yeast (C. albicans) and pathogenic protozoans (Trichomonas vaginalis) , and could destroy pathogens within one hour of contact suggesting faster and complete destruction of pathogens. (data on file)

Effect of silver nanoparticles on Candida albicans, Trichomonas vaginalis, Pseudomonas aeruginosa

Silver nanoparticles (40 ppm) has demonstrated antifungal activity against C. albicans, antibacterial activity against P. aeruginosa and antiparasitic activity against Trichomonas vaginalis. (data on file)

Effect of SilverSol® Solution (32 ppm) and Amorphous Hydrogel with Colloidal Silver, Vagigel (32 ppm) on C. albicans, T. vaginalis, P. aeruginosa and Lactobacillus acidophilus in an Experimental Mouse Model of Vaginitis

SilverSol® Solution (32ppm) and Amorphous Hydrogel with Colloidal Silver, Vagigel (32 ppm) showed activity against C. albicans, T. vaginalis, P. aeruginosa but no effect on growth of L. acidophilus suggesting that both the products have antifungal, antibacterial and anti-parasitic activity and causes no harm to normal vaginal lactobacillus flora. (data on file)

The in vitro efficacy of betadine antiseptic solution and colloidal silver gel combination in inhibiting the growth of bacterial biofilm

The combination of 5% Betadine solution and Ag-gel completely inhibits the growth of bacterial biofilms including of K. penumoniae CI.

Phat Tran, Keaton Luth, Huy Dong, et al. The in vitro efficacy of betadine antiseptic solution and colloidal silver gel combination in inhibiting the growth of bacterial biofilms. 2020. doi: 10.20944/preprints202002.0419.v1.

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The ability of a colloidal silver gel wound dressing to kill bacteria in vitro and in vivo

Colloidal silver gel has shown complete inhibition of Staphylococcus aureus, Pseudomonas aeruginosa and Acinetobacter baumannii and the formation of biofilms when place on dressing in a mouse wound model.

P.L. Tran, E. Huynh, A.N. Hamood, et al. The ability of a colloidal silver gel wound dressing to kill bacteria in vitro and in vivo. J Wound Care. 2017 ;26:S16-S24.

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A randomized Double-blind study comparing sodium feredetate with ferrous fumarate in anaemia in pregnancy

Sodium feredetate with ferrous fumarate has shown effective improvement in haemoglobin profile in pregnant anaemic women.

Sarkate P, Patil A, Parulekar S, et al. A randomized Double-blind study comparing sodium feredetate with ferrous fumarate in anaemia in pregnancy. J Indian Med Assoc.2007 ;105(5):278, 280-1.

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An evaluation of sodium feredetate for the treatment of iron deficiency anaemia in Indian patients

An Indian study showed the efficacy of sodium feredetate (NaFeEDTA) in improving iron status in anaemic pregnant women suggesting sodium feredetate to be a promising hematinic for patients with iron-deficiency anaemia.

Prateek S, Saxena P, Fotedar V, et al. An evaluation of sodium feredetate for the treatment of iron deficiency anaemia in Indian patients. J Obs Gynae. 2005; 7:385-390.

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